Recombinant Rat MCP-1

Monocyte chemotactic protein-1 (MCP-1) is an essential chemokine produced predominantly by macrophages and endothelial cells and is a potent chemotactic factor for monocytes.^1,2,3 It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer). MCP-1 is also a potent activator of human basophils, induces degranulation and the release of histamines. MCP-1 is involved in the pathogenesis of atherosclerosis and myocardial infarction.⁴

Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN

Lyophilized

The molecular weight of Recombinant Rat MCP-1 is Mr 14.1 kDa.

The sterile filtered solution was lyophilized with no additives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Yoshimura, T. et al. (1989) J. Exp. Med. 169: 1449
2. Oppenheim, JJ. et al. (1989) J. Exp. Med. 169: 1485
3. Rollins, BJ. et al. (1997) Blood 90: 909
4. Benjamin, EJ. et al. (2005) Ciculation 112: 1113