Recombinant Rat MIP-1α

Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a potent inhibitor of hemopoietic stem cell proliferation and is a member of a family of pro- inflammatory mediators, the chemokine family.¹ MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells.² The role of MIP-1 alpha seems to be related to production of TNF-alpha, which in turn up-regulates vascular adhesion molecules required for neutrophil influx.³

Lyophilized

Recombinant Rat MIP-1a is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7853 Dalson.

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

1. IB Pragnell et al. (1994) J. Biol. Chem. 269: 4974 2. DN Cook et al. (1996) J. of Leukocyte Biol. 59: 61 3. PA Ward et al. (1995) J of Immunol. 154: 4793